Dr. Gérard Simonneaux Biorganics, catalysis and metalloproteins   Phone : 33 (0) 2 23 23 62 85 Fax : 33 (0) 2 23 23 56 37

Research Group

• Catalysis
  • G. Simonneaux
  • A. Bondon
  • P. Le Maux
  • C. Paul-Roth

   

• Metalloporphyrins and Hemoproteins
• G. Simonneaux
• A. Bondon

 

• Porphyrins and Photosensitizers
• G. Simonneaux
• P. Le Maux

 

Research topics

Catalysis

The main goal is to prepare new metal porphyrins as catalysts for organic synthesis. Regioselective and stereoselective additions (or insertion) of carbenes are studied for the enantioselective formation of C-C and C-O bonds. The synthesis of catalysts for oxidation of inert organic molecules is developed in order to find application in detoxification.

• Ruthenium porphyrins
• Fluorinated porphyrins (Fe,Mn)
• Optically active porphyrins and chiral recognition

 

Metalloporphyrins and Hemoproteins

The study of the active site of hemoproteins using model compounds and NMR is the main purpose of the work. NMR studies of paramagnetic iron porphyrins and paramagnetic hemoproteins are particularly developed.

• electronic structure of ferric porphyrins
• mechanism of electron transfer (hemoglobin, cytochromes c and P450)

Porphyrins and Photosensitizers

The main objective is to prepare new photosensitizers for application in photodynamic therapy. Protein-porphyrin coupling is developed in order to increase tumor specificity.

Recent publications

Synthesis of new 9,9'-spirobifluorene porphyrins
C.Poriel, Y. Ferrand, P. Le Maux and G. Simonneaux
Synlett. 2003, 71-74

1H NMR and EPR studies of Low-spin iron(III) phosphonite mesotetraphenylporphyrin complexes : a new (dxz, dyz)4 (dxy)1 configuration from 293 K to 4K
M. Kobeissi and G. Simonneaux
Inorg. Chim. Acta 2003, 343, 18-26.

Hydroporphyrins as tumour photosensitizers: synthesis and photophysical studies of 2,3- dihydro-5,15-di(3,5-didihydroxyphenyl)porphyrin
Y. Ferrand, L. Bourré, G. Simonneaux, S. Thibaut, F. Odobel, Y. Lajat and T. Patrice
Biorg. Med. Chem. Lett., 2003, 13, 833-835.

Electronic Structure of Iron Chlorins : Characterization of bis(L-valine methyl ester)(meso-tetraphenylchlorin)iron(III)triflate and Bis(L-valine methyl ester)(meso-tetraphenylchlorin iron(II)
G. Simonneaux, M. Kobeissi and L. Toupet
Inorg. Chem. 2003, 42, 1644-1651.

Syntheses of manganese tetraspirobifluoreneporphyrins as new catalysts for oxidation of alkenes by hydrogen peroxide and iodosylbenzene.
Cyril Poriel, Yann Ferrand, Paul Le Maux and Gérard Simonneaux, Tetrahedron Lett. 2003, 44, 1759-1761

Cyclopropanation of alkenes with diisopropyl diazomethylphosphonate
Catalysed by ruthenium porphyrin complexes
Christine Paul-Roth, Fédéric De Montigny, Gildas Rethoré, Gérard Simonneaux, Mihaela Gulea and Serge Masson J. Mol. Cat. A, 2003, 201, 79-91

Vectorisation of diphenylchlorin sensitiser in liposomes for photodynamic therapy
L. Bourré, S. Thibaut, M. Fimiani, Y. Ferrand, G. Simonneaux and T. Patrice
Pharmacol. Res. 2003, 47, 253-261.

Poly(9,9'-spirobifluorene-manganese porphyrin) : a new catalytic material for oxidation of alkenes by iodobenzene diacetate and iodosylbenzene.
Cyril Poriel, Yann Ferrand, Paul Le Maux, Joelle Rault-Berthelot and Gérard Simonneaux, J. Chem. Soc. Chem. Commun., 2003, 1104-1105

Carbene complexes of metalloporphyrins and heme proteins
G. Simonneaux and P. Le Maux
The Porphyrin Handbook, Khadish, K. M.; Smith, K. M.; Guilard, R. Eds, 2003, Vol 11, 133-159.

Evaluation of a diphenylchlorin sensitiser for photodynamic therapy: synthesis and in vitro evaluation
L. Bourré, G. Simonneaux, Y. Ferrand, S. Thibaut, Y. Lajat and T. Patrice
J. PhotoChem. PhotoBiol., 2003, 69, 179-192.

Spirometalloporphyrin materials for catalytic reactions
G. Simonneaux, C. Poriel, Y. Ferrand, J. Rault-Berthelot
Progress in Coordination and Bioinorganic Chemistry, 2003, Vol. 6, 77-82